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该剧根据柯南·道尔的《夏洛克·福尔摩斯》系列小说改编，背景从原作的19世纪末伦敦转移至现代纽约，讲述天赋异禀、擅长推理演绎的前苏格兰场顾问夏洛克·福尔摩斯，因药物上瘾而来到纽约的康戒中心修养，并担任当地警方的顾问。在生活重新渐渐回到正轨后，夏洛克结识一位名叫琼恩·华生的戒断看护，二人搭档参与解决了众多疑难案件。不过……许负欲言又止。顾及到梁家的名声和母亲关惠兰（薛家燕 饰）的感受，梁正尧同梁家彻底断绝了关系，可是他的弟弟梁正匡（陈锦鸿 饰）却并不明白哥哥的一片苦心，误会梁正尧是忘恩负义之人。一怒之下，梁正匡决定依靠自己的力量开设酒坊，成为哥哥的竞争对手，同哥哥势不两立。一晃眼多年过去，失踪已久的宋家长子宋子骏（敖嘉年 饰）忽然现身，在宋、梁两个家族之间掀起了狂风暴雨。《七年之痒》讲诉了三对性格、家庭迥异的夫妻，主要以魏海东（华少）和陈晓荷（文清）为主角。年过三十五岁的魏海东和妻子陈晓荷在这个城市里过着都市白领的生活，他们的婚姻走过了七个年头，到了所谓七年之痒的阶段，他们曾经不相信这种普通人总结的情况会出现在自己身上，但当时间一点点流逝，当爱情的甜美被生活的现实一点点蚕食，情感裂痕开始出现，婚姻的大厦一下子显得岌岌可危。"No one in position 149 was completely unstung, I am no exception, He got several times during the fight, But I'm lucky, None of them stung the key parts, Two big flying wasps stung me in this area of my chest. Luckily there was a bullet bag hanging on it, The bullet bag was stuffed with four shuttles (note: the shuttle here refers to the magazine of an automatic rifle). Four shuttles covered the whole chest, So it blocked the two poison needles directly, No matter how severe the poison needle is, of course it cannot penetrate the shuttle. Just pierced the canvas on the bullet bag, It was hung on it, but although it could not be tied through the shuttle, it could still pass through the slightly thinner metal, because I had been hit several times in my head. When the battle was completely over, I had five poisonous needles on my head, each of which was the front tip already stuck in and the back half was exposed. I was wearing a helmet at that time! Even helmets can be tied up. No wonder several comrades with cloth hats have their skulls nailed through.这是一部关于讲述恋爱经验、恋爱基因有着“缺失”的3男3女之间的恋爱群像剧。当恋爱经验为零、认为自己的人生不需要爱情的樱泽纯（广濑爱丽丝 饰），因为一顿午餐遇见了擅长带给女性疗愈感的天才、刹那恋爱主义者长峰柊磨（松村北斗 饰）后，开启了一段苦恋。最终对爱情玩世不恭的长峰柊磨爱上了纯，两人走到了一起。性格内向、恐惧恋爱的便利店店员·内村克己因为一次受邀，爱上了只看重恋爱性价比、恋爱关系中只追求自己利益最大化的真山有纱（饭丰万理江 饰）。克己虽木讷但用情专一，有纱的恋爱观因为与克己的相处发生了巨大的变化，最终有情人终成眷属。比起轰轰烈烈的爱情更注重安稳的生活、选择与初恋结婚却过着压抑生活清宫响子（西野七濑 饰）认识了厨艺及长相都超一流、身有隐情谜团重重的天才厨师岩桥要，也在与阿要的相识后中感受到了温暖。最终响子直面内心，选择了与长期冷落自己的丈夫离婚，她与去巴黎3年深造的岩桥要约定，等着他回来。只说了一句：大哥小心些。